Using Chitosan or Chitosan Derivatives in Cancer Therapy

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-10-13 DOI:10.3390/polysaccharides2040048

Md. Salman Shakil, Kazi Mustafa Mahmud, M. Sayem, Mahruba Sultana Niloy, S. Halder, Md. Sakib Hossen, Md. Forhad Uddin, Md. Ashraful Hasan

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引用次数: 23

Abstract

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

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壳聚糖及其衍生物在癌症治疗中的应用

癌症是世界范围内死亡的主要原因之一。化疗药物已成为抗癌药物的热门选择。尽管化疗药物有治疗效果，但患者经常会遇到副作用和耐药性。生物聚合物可以用来克服化疗药物的一些局限性，也可以用作抗癌剂或药物输送载体。壳聚糖是一种从甲壳素中提取的生物相容性聚合物。壳聚糖、壳聚糖衍生物或壳聚糖纳米颗粒已显示出其作为抗癌剂的前景。此外，功能修饰的壳聚糖可用于递送核酸、化疗药物和抗癌药物。更重要的是，壳聚糖为基础的药物传递系统提高了这些抗癌药物的功效、效力、细胞毒性或生物相容性。本文就壳聚糖及其化学修饰壳聚糖衍生物的性质及其在癌症治疗中的应用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Natural Polysaccharides in Drug Delivery and Biomedical Applications

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