A Brief Update on STAT3 Signaling: Current Challenges and Future Directions in Cancer Treatment

Abstract

Due to its importance in a wide range of cellular processes, including cell proliferation, apoptosis, and immune evasion, the signal transducer and activator of transcription (STAT) 3 signaling pathway has been studied intensively over the past few decades. Dysregulation of the STAT3 signaling pathway is closely associated with initiation and development of various types of hematologic or solid malignancies (approximately 70% of those appearing in humans) [1].