The Growing Potential of Neurophysiology in Multiple Sclerosis

Canham Ljw, D. Western, P. Walsh, N. Kane, K. Inglis, D. Cottrell
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Abstract

Neurophysiological techniques have a long history of clinical and research use in the setting of Multiple Sclerosis. With the output of evoked potential and electroencephalographic recordings being a direct consequence of the underlying functional integrity and activity of the nervous system it is unsurprising there is currently a resurgent interest in their possible use as biomarkers of disease related dysfunction. Herein we discuss the promise and possible pitfalls associated with their use in translational research of MS therapeutics. The numerous advantages of these methods are touched upon as demonstrated by their application to date. A number of obstacles which must be overcome prior to their successful widespread implementation are also outlined and readily achievable solutions discussed.
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神经生理学在多发性硬化症中的发展潜力
神经生理学技术在多发性硬化症的临床和研究中有着悠久的历史。由于诱发电位和脑电图记录的输出是神经系统潜在功能完整性和活动的直接结果,因此,目前对它们作为疾病相关功能障碍的生物标志物的可能用途重新产生兴趣就不足为奇了。在这里,我们讨论了与它们在多发性硬化症治疗的转化研究中使用相关的希望和可能的陷阱。这些方法的众多优点被它们迄今为止的应用所证明。还概述了在成功广泛实施之前必须克服的一些障碍,并讨论了容易实现的解决办法。
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