{"title":"4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶的合成与分析 Synthesis and Analysis of 4-Methyl-2-[(3,5-Dimethyl-4-Methoxy-2-Pyridine)Methylmercapto]-Pyrimidine","authors":"陈向莹, 范芳芳, 夏佳美, 张千峰","doi":"10.12677/JOCR.2016.44015","DOIUrl":null,"url":null,"abstract":"以2-巯基-4-甲基嘧啶盐酸盐为原料，与2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐、甲醇钠反应，合成4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶。并通过1H NMR、FT-IR表征手段，对产物4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶进行谱学分析。 4-Methyl-2-[(3,5-dimethyl-4-methoxy-2-pyridine)methylmercapto]-pyrimidine was efficiently synthesized by reaction of 2-mercapto-4-methylpyrimidine hydrochloride and 2-chloromethyl-3,5- dimethyl-4-methoxypyridine hydrochloride in the presence of sodium methoxide. The product was well characterized by 1H NMR and FT-IR spectroscopies.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"95 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12677/JOCR.2016.44015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
以2-巯基-4-甲基嘧啶盐酸盐为原料，与2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐、甲醇钠反应，合成4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶。并通过1H NMR、FT-IR表征手段，对产物4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶进行谱学分析。 4-Methyl-2-[(3,5-dimethyl-4-methoxy-2-pyridine)methylmercapto]-pyrimidine was efficiently synthesized by reaction of 2-mercapto-4-methylpyrimidine hydrochloride and 2-chloromethyl-3,5- dimethyl-4-methoxypyridine hydrochloride in the presence of sodium methoxide. The product was well characterized by 1H NMR and FT-IR spectroscopies.
4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶的合成与分析 Synthesis and Analysis of 4-Methyl-2-[(3,5-Dimethyl-4-Methoxy-2-Pyridine)Methylmercapto]-Pyrimidine
以2-巯基-4-甲基嘧啶盐酸盐为原料，与2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐、甲醇钠反应，合成4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶。并通过1H NMR、FT-IR表征手段，对产物4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶进行谱学分析。 4-Methyl-2-[(3,5-dimethyl-4-methoxy-2-pyridine)methylmercapto]-pyrimidine was efficiently synthesized by reaction of 2-mercapto-4-methylpyrimidine hydrochloride and 2-chloromethyl-3,5- dimethyl-4-methoxypyridine hydrochloride in the presence of sodium methoxide. The product was well characterized by 1H NMR and FT-IR spectroscopies.
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