Painless Cervical Lymphadenopathy in an Elderly Patient - A Rare Case of Rosai-Dorfman Disease and Hodgkin's Lymphoma

Tan Shi Ying, Telisinghe Pemasiri Upali, Keasberry Justin Fook Siong
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Abstract

Rosai-Dorfman disease is a rare, benign disease presenting with extensive lymphadenopathy. In this case, an 81-yearold gentleman with previous pulmonary tuberculosis, presented with painless cervical lymphadenopathy associated with generalized weakness, loss of appetite, and cough. The causes of cervical lymphadenopathy in elderly are comprehensive; hence thorough history taking, examination, and appropriate investigations are vital in diagnosing diseases. If blood investigations and imaging are inconclusive, a lymph node biopsy is recommended. He was later diagnosed with Rosai-Dorfman disease associated with Hodgkin’s lymphoma and dexamethasone treatment was initiated. Concomitant diagnoses are rare, but should not disregarded. Regular monitoring is required as immune dysregulation may exacerbate quiescent, treated pulmonary tuberculosis.
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老年患者无痛性颈淋巴肿大-一例罕见的罗赛-多夫曼病和霍奇金淋巴瘤
Rosai-Dorfman病是一种罕见的良性疾病,表现为广泛的淋巴结病变。在本病例中,一位81岁的男性既往患有肺结核,表现为无痛性颈淋巴肿大伴全身无力、食欲不振和咳嗽。老年人颈淋巴肿大的病因是全面的;因此,彻底的病史记录、检查和适当的调查对诊断疾病至关重要。如果血液检查和影像学不确定,建议进行淋巴结活检。后来,他被诊断出患有与霍奇金淋巴瘤相关的罗赛-多夫曼病,并开始了地塞米松治疗。伴随的诊断是罕见的,但不应忽视。定期监测是必要的,因为免疫失调可能加剧静止的、治疗过的肺结核。
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