A. Kebriaeezadeh, A. Zarghi, R. Ahmadkhaniha, A. Khoddam, A. Ebrahimian
{"title":"Simultaneous High‐Performance Liquid Chromatographic Determination of Sulphamethoxazole and Trimethoprim in the Plasma of Man","authors":"A. Kebriaeezadeh, A. Zarghi, R. Ahmadkhaniha, A. Khoddam, A. Ebrahimian","doi":"10.1211/146080800128735737","DOIUrl":null,"url":null,"abstract":"An HPLC method has been developed for simultaneous analysis of sulphamethoxazole (SMZ) and trimethoprim (TMP) in plasma from man. The detection limits for TMP and SMZ in plasma were 5 and 10ng mL−1, respectively. The average recovery for both compounds was 96% (approx.). The inter- and intra-day coefficients of variation of the assay were found to be less than 8%. \n \n \n \nThe method is simple, sensitive and suitable for pharmacokinetic studies of sulphamethoxazole and trimethoprim.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"47 1","pages":"113-115"},"PeriodicalIF":0.0000,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128735737","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
An HPLC method has been developed for simultaneous analysis of sulphamethoxazole (SMZ) and trimethoprim (TMP) in plasma from man. The detection limits for TMP and SMZ in plasma were 5 and 10ng mL−1, respectively. The average recovery for both compounds was 96% (approx.). The inter- and intra-day coefficients of variation of the assay were found to be less than 8%.
The method is simple, sensitive and suitable for pharmacokinetic studies of sulphamethoxazole and trimethoprim.
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