{"title":"Application of critical flicker fusion frequency and oculomotor measures in the evaluation of drug effects on central functions","authors":"H. Zhan","doi":"10.3760/CMA.J.ISSN.1007-6239.2014.02.023","DOIUrl":null,"url":null,"abstract":"Objective To review the researches on the application of critical flicker fusion frequency (CFF) and oculomotor measures in the evaluation of drug effects on central functions.Literature resource and selection Relevant articles and monographs published in China and abroad.Literature quotation Seventy-six published references (73 papers and 3 monographs) were cited.Literature synthesis The research advances on the application of CFF and oculomotor measures in the evaluation of drug effects on central functions were reviewed.CFF measure was a simple and convenient method for central vigilance and fatigue evaluation.The main indices or parameters of oculomotor responsive measures were initial pupil diameter or area,constriction latency of pupil to light flash,amplitude of pupil constriction to light flash,saccadic velocity,saccadic amplitude,etc..Many studies at home and abroad showed that CFF and oculomotor responsive measures could be used for evaluating the central effects of following drugs:sedative hypnotics,histamine H1 receptor antagonists,antidepressants,central stimulants,alcohol,opiates and so on.Saccadic velocity was a sensitive index for assessing the sedative effects of these drugs.Pupil measures could be used for evaluating the awaking action of drug and its effects on autonomic nerve function,and were also sensitive to the central effects of alcohol and opiates.Conclusions CFF and oculomotor response measures have been widely applied in the evaluation of the central effects of different kinds of drugs and the medication safety for special population. \n \nKey words: \nFlicker fusion; Pharmaceutical preparations; Central nervous system; Review literature; Oculomotor responses","PeriodicalId":9904,"journal":{"name":"中华航空航天医学杂志","volume":"42 4 1","pages":"149-158"},"PeriodicalIF":0.0000,"publicationDate":"2014-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华航空航天医学杂志","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2014.02.023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Objective To review the researches on the application of critical flicker fusion frequency (CFF) and oculomotor measures in the evaluation of drug effects on central functions.Literature resource and selection Relevant articles and monographs published in China and abroad.Literature quotation Seventy-six published references (73 papers and 3 monographs) were cited.Literature synthesis The research advances on the application of CFF and oculomotor measures in the evaluation of drug effects on central functions were reviewed.CFF measure was a simple and convenient method for central vigilance and fatigue evaluation.The main indices or parameters of oculomotor responsive measures were initial pupil diameter or area,constriction latency of pupil to light flash,amplitude of pupil constriction to light flash,saccadic velocity,saccadic amplitude,etc..Many studies at home and abroad showed that CFF and oculomotor responsive measures could be used for evaluating the central effects of following drugs:sedative hypnotics,histamine H1 receptor antagonists,antidepressants,central stimulants,alcohol,opiates and so on.Saccadic velocity was a sensitive index for assessing the sedative effects of these drugs.Pupil measures could be used for evaluating the awaking action of drug and its effects on autonomic nerve function,and were also sensitive to the central effects of alcohol and opiates.Conclusions CFF and oculomotor response measures have been widely applied in the evaluation of the central effects of different kinds of drugs and the medication safety for special population.
Key words:
Flicker fusion; Pharmaceutical preparations; Central nervous system; Review literature; Oculomotor responses
期刊介绍：
The aim of Chinese Journal of Aerospace Medicine is to combine theory and practice, improve and popularize, actively advocate a hundred flowers bloom and a hundred schools of thought contend, advocate seeking truth from facts, promote the development of the related disciplines of aerospace medicine and human efficiency, and promote the exchange and penetration of aerospace medicine and human efficiency with other biomedical and engineering specialties.
Topics of interest for Chinese Journal of Aerospace Medicine include:
-The content of the journal belongs to the discipline of special medicine and military medicine, with the characteristics of multidisciplinary synthesis and cross-penetration, and mainly reflected in the aerospace industry, aerospace flight safety and efficiency, as well as the synthesis of special medicine, preventive medicine, environmental medicine, psychology, etc.
-Military aeromedicine (Air Force, Navy and Army aeromedicine) and civil aeromedicine, with a balance of aerospace medicine are the strengths of the journal.
-The change in aerospace medicine from a focus on promoting physiological compensatory adaptations to enhancing human performance under extreme environmental conditions is what the journal is helping to promote.
-The expansion of manuscripts in high altitude medicine is also a special emphasis of the journal.
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