Synthesis of triazine linked pyrazole heterocyclics by conventional heating and microwave irradiative cyclocondensation and evaluation of antitubercular and antimicrobial potential

Abstract

The synthesis of (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted phenyl/ H -pyrazol-3-yl)- amines and (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl/cinnamoyl-pyrazol-3-yl)-amines by conventional heating and microwave irradiative cyclocondensation have been achieved by the cyclisation of N-(4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-3-oxo butyramide with substituted hydrazines and acid hydrazides. The required butyramide has been synthesized by the reaction of 2,4-diamino-6-methyl-[1,3,5]-triazine with benzaldehyde followed by the condensation with ethyl acetoacetate. Structural elucidation of synthesized compounds has been performed by IR, 1 H NMR and mass spectral studies besides chemical transformation and elemental analysis. The title compounds have been evaluated for their antitubercular and antimicrobial potential against some selected microorganisms to establish the structure activity relationship.