Study of intestinal metaplasia in Barrett’s esophagus

Zhang Shasha, Z. Jun, Luo Jinyan, Wang Kangming, Gong Jun, Zuo Aili
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Abstract

OBJECTIVE: The aim of the present study was to investigate the factors predisposing patients with Barrett’s esophagus (BE) to intestinal metaplasia (IM). METHODS: Forty-seven BE patients were studied. By using endoscopic and histological methods, esophageal IM was diagnosed in 36 patients, who were compared with 11 patients without IM in regard to their age, the endoscopic appearance of the esophagus and esophageal motility. RESULTS: The patients’ age and endoscopic features of the esophagus, but not esophageal motor function and grade of macroscopic esophagitis, were risk factors for the development of IM. CONCLUSIONS: Patient age and endoscopic features of the BE mucosa are associated with IM and may be prognostic factors for BE.
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Barrett食管肠化生的研究
目的:探讨Barrett食管(BE)患者肠化生(IM)的易感因素。方法:对47例BE患者进行研究。通过内镜和组织学方法,36例患者被诊断为食管IM,并与11例无IM的患者在年龄、食管内镜外观和食管运动方面进行比较。结果:患者的年龄和食管内镜特征是IM发生的危险因素,而食管运动功能和食管炎的宏观程度不是IM发生的危险因素。结论:患者年龄和BE粘膜的内窥镜特征与IM相关,可能是BE的预后因素。
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