Identification of Bladder Cancer at early age in Iraq used by Tumor Marker and Genes Characterization

Abstract

Cancer is mostly considered as a 30 % genetic disease so much so that this disease, which defines a multi-step neoplasia characterized by tumor formation and cell proliferation becomes uncontrolled, depends on the individual's genetic predisposition.Bladder tumors are clinically characterized by their high recurrence rate once they invade the muscle layerwhich added clinical value as diagnostic and prognostic biomarkers in bladder cancer. Progress of the high-impact technologies for molecular analysis of tumors allow explore genetic profiles, epigenetic and protein characteristic different tumor subtypes and identify targets and molecular pathways that define a specific clinical behavior. Objective to evaluate the Bladder Tumor Marker (BTM) as a new developed tumor marker in comparison to cytology in the selected area.The present study contributes to a growing body of work on gene expression signatures in bladder cancer and urine samples collection from Bladder cancer early detection center at Nineveh health department, Al-khansa Teaching Hospital in Mosul during the study period patients N: 101 and controls N: 19 .The final study is to establish a concept of stratification of patients with bladder cancer. For this, we have developed a multi-parameter test for the quantification of the selected biomarkers.