Nucleic acid functionalized extracellular vesicles as promising therapeutic systems for nanomedicine

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-01-01 DOI:10.20517/evcna.2021.21

Chunping Liu, Dongyue He, Huan Cen, Huiqi Chen, Longmei Li, G. Nie, Zixue Zhong, Qingfeng He, Xiaofei Yang, Sien Guo, Lei Wang, Zhijin Fan

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引用次数: 14

Abstract

Extracellular vesicles (EVs), as natural carriers, are regarded as a new star in nanomedicine due to their excellent biocompatibility, fascinating physicochemical properties, and unique biological regulatory functions. However, there are still some challenges to using natural EVs, including poor targeting ability and the clearance from circulation, which may limit their further development and clinical use. Nucleic acid has the functions of programmability, targeting, gene therapy, and immune regulation. Owing to the engineering design and modification by integrating functional nucleic acid, EVs offer excellent performances as a therapeutic system in vivo. This review briefly introduces the function and mechanism of nucleic acid in the diagnosis and treatment of diseases. Then, the strategies of nucleic acid-functionalized EVs are summarized and the latest progress of nucleic acid-functionalized EVs in nanomedicine is highlighted. Finally, the challenges and prospects of nucleic acid-functionalized EVs as a promising diagnostic system are proposed.

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核酸功能化的细胞外囊泡是纳米医学中有前景的治疗系统

细胞外囊泡(Extracellular vesicles, ev)作为一种天然载体，以其优异的生物相容性、迷人的物理化学性质和独特的生物调控功能，成为纳米医学领域的一颗新星。然而，天然电动汽车仍存在一些挑战，包括靶向能力差和循环清除，这可能限制其进一步开发和临床应用。核酸具有可编程性、靶向性、基因治疗和免疫调节功能。通过整合功能性核酸的工程设计和改造，ev作为一种体内治疗系统具有优异的性能。本文就核酸在疾病诊断和治疗中的作用及机制作一简要介绍。总结了核酸功能化电动汽车的发展策略，重点介绍了核酸功能化电动汽车在纳米医学领域的最新进展。最后，提出了核酸功能化电动汽车作为一种有前景的诊断系统所面临的挑战和前景。

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Extracellular vesicles and circulating nucleic acids

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4.10

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