A hybrid convolutional neural network-extreme learning machine with augmented dataset for dna damage classification using comet assay from buccal mucosa sample
Yues Tadrik Hafiyan, Afiahayati, Ryna Dwi Yanuaryska, Edgar Anarossi, V. Sutanto, J. Triyanto, Y. Sakakibara
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引用次数: 3
Abstract
DNA is the information carrier in cells that are susceptible to damage, either naturally or due to external influences. Comet assays are often used by experts to determine the level of damage. However, the comet assays gathered with swab technique (Buccal Mucosa for example) often produced a higher noise level compared to ones that are cell-cultured, thus, making the analysis process more difficult. In this research, we proposed a novel way to assess the degree of damage from Buccal Mucosa comet assays using a hybrid of Convolutional Neural Network (CNN) and Extreme Learning Machine (ELM). The CNN was used to capture and extract spatial relation from every comet, while the ELM was used as a classifier that can minimize the risk of vanishing gradient. Our hybrid CNN-ELM model scored 96.96% for accuracy, while the VGG16-ELM scored 88.4% and ResNet50-ELM 76.8%.
期刊介绍:
The primary aim of the International Journal of Innovative Computing, Information and Control (IJICIC) is to publish high-quality papers of new developments and trends, novel techniques and approaches, innovative methodologies and technologies on the theory and applications of intelligent systems, information and control. The IJICIC is a peer-reviewed English language journal and is published bimonthly