Ayu Matsunaga, Kurumi Takagi-Matsumoto, M. Yamashita, Kumiko Kizu-Mori, Junko Hirose, T. Kabuki, F. Sakai, Hiroshi Narita
{"title":"Lactobacillus gasseri SBT2055 Enhances Oral Tolerance in Mice via Breastfeeding","authors":"Ayu Matsunaga, Kurumi Takagi-Matsumoto, M. Yamashita, Kumiko Kizu-Mori, Junko Hirose, T. Kabuki, F. Sakai, Hiroshi Narita","doi":"10.4327/JSNFS.72.105","DOIUrl":null,"url":null,"abstract":"Summary : Maternal administration of probiotics is known to be effective for prevention of allergic symptoms in babies by suppressing the immune reaction to orally ingested proteins ( oral tolerance ) . We investigated whether breast milk nourishment by mother mice that had been orally administrated Lactobacillus gasseri SBT 2055 ( LG 2055) with food antigen contributed to allergy prevention in their pups. Female BALB/c mice ( dams ) were fed a diet containing casein ( C group ) , egg white ( E group ) , or egg white with LG 2055 ( E + LG group ) . After induction of pregnancy, pups fed on their dam ʼ s milk were systemically immunized with ovalbu-min ( OVA ) . Then, at the age of seven weeks, the pups were given an intragastric OVA challenge. The incidence of diarrhea was significantly suppressed in pups of the E + LG group relative to the E group. Moreover, the amounts of total IgA and OVA-specific IgA immune complex ( IgA-IC ) in the breast milk were significantly in-creased by administration of LG 2055 . These findings suggest that the increase of IgA-IC in breast milk by LG 2055 might closely correlate with enhancement of oral tolerance in pups.","PeriodicalId":19296,"journal":{"name":"Nippon Eiyo Shokuryo Gakkaishi","volume":"23 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nippon Eiyo Shokuryo Gakkaishi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4327/JSNFS.72.105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Summary : Maternal administration of probiotics is known to be effective for prevention of allergic symptoms in babies by suppressing the immune reaction to orally ingested proteins ( oral tolerance ) . We investigated whether breast milk nourishment by mother mice that had been orally administrated Lactobacillus gasseri SBT 2055 ( LG 2055) with food antigen contributed to allergy prevention in their pups. Female BALB/c mice ( dams ) were fed a diet containing casein ( C group ) , egg white ( E group ) , or egg white with LG 2055 ( E + LG group ) . After induction of pregnancy, pups fed on their dam ʼ s milk were systemically immunized with ovalbu-min ( OVA ) . Then, at the age of seven weeks, the pups were given an intragastric OVA challenge. The incidence of diarrhea was significantly suppressed in pups of the E + LG group relative to the E group. Moreover, the amounts of total IgA and OVA-specific IgA immune complex ( IgA-IC ) in the breast milk were significantly in-creased by administration of LG 2055 . These findings suggest that the increase of IgA-IC in breast milk by LG 2055 might closely correlate with enhancement of oral tolerance in pups.