Methanol extract of Solanum violaceum root possesess antiobesity, hypolipidemic, thrombolytic and membrane stabilizing activity

Abstract

http://doi.org/10.12991/mpj.2018.47 Marmara Pharm J 2018;22(1): 96-102 Corresponding Author: Mohammad Salim Hossain E-mail: Email: pharmasalim@yahoo.com Phone: +8801711200410 ORCID No: 0000-0002-5710-1115 Received: 14.05.2017 / Accepted: 03.10.2017 ABSTRACT: Roots of Solanum violaceum (S. violaceum) is used traditionally in different therapeutic applications in Bangladesh. Root extract of S. violaceum was investigated for total phenolic content (TPC), antiobesity, anti-hyperlipidemic, membrane stability and thrombolytic activity. Total phenolic content (TPC) was determined using folin-ciocalteu method. High fat diet induced obese mice were used for anti obesity and antihyperlipidemic test. Body weight gain, blood total cholesterol, triglyceride level were analyzed. Thrombolytic and membrane stability activity were evaluated by using human erythrocytes. Total phenolic content in root extract of S. violaceum was calculated as 51.26 mg gallic acid equivalent GAE/g of dry weight. The extractive supplementation with dose of 200mg/ kg and 400mg/kg were capable of lowering the level of triglyceride and total cholesterol significantly (p<0.05) in high fat diet (HFD) induced obese mice in a dose dependent manner. As a membrane stabilizing agent, crude extract was able to inhibit the erythrocyte heamolysis significantly (p< 0.05) with a value of 28.02±5.09% and 32.97± 4.12% respectively for heat and hypotonic solution induced condition. Moreover, 21.56 ±2.62 % of clot lysis was exhibited by the extract for its thrombolytic activity. The root of S. violaceum justifies its potential as anti obese agent. Further research is recommended to find out the active metabolites from this source.