Association of Serum Magnesium Concentration with Alzheimer’s Disease

Bangladesh Journal of Neuroscience Pub Date : 2017-07-31 DOI:10.3329/bjn.v33i2.57520

M. Uddin, M. Habib, Md. Rafiqul Islam, M. R. K. Khan, H. Z. Rahman, A. N. Rizvi, M. Bhuiyan, K. K. Barman, Syeeda Showkat, Hannan Ma, Imran Sarker

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Abstract

Background: Alzheimer’s disease is a neurodegenerative disease. It is the most common cause of dementia in individuals older than 60 years of age. Age is the most important risk factor for Alzheimer’s disease. It is important to identify modifiable risk factors. One such important modifiable risk factor is Magnesium, a trace element. The objective of the study was to see the association of serum Magnesium concentration with Alzheimer’s disease patients. Method: It was a case control study carried out in neurology department of BSMMU, Dhaka. Total 68 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 34 were grouped as case and rest 34 were control. Serum Magnesium concentration was detected. Result: Serum Magnesium concentration was significantly lower in AD patients than that of control group [2.04±0.19 mg/dl vs 2.36±0.21 mg/dl. Conclusion: The results of our study revealed an expression that the trace element, Magnesium concentration has an association with Alzheimer’s disease. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 70-75

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血清镁浓度与阿尔茨海默病的关系

背景:阿尔茨海默病是一种神经退行性疾病。它是60岁以上老年人痴呆症的最常见原因。年龄是阿尔茨海默病最重要的风险因素。确定可改变的风险因素是很重要的。其中一个重要的可改变的危险因素是镁，一种微量元素。该研究的目的是观察血清镁浓度与阿尔茨海默病患者的关系。方法:在达卡BSMMU神经内科进行病例对照研究。在满足纳入和排除标准后，共纳入68例患者作为研究人群。其中34例为病例，其余34例为对照组。检测血清镁浓度。结果:AD患者血清镁浓度明显低于对照组(2.04±0.19 mg/dl vs 2.36±0.21 mg/dl)。结论:我们的研究结果揭示了微量元素镁浓度与阿尔茨海默病的关系。孟加拉国神经科学杂志2017;Vol. 33 (2): 70-75

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Bangladesh Journal of Neuroscience

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