E. Leonova, Kristīne Dišlere, E. Rostoka, L. Baumane, E. Bisenieks, G. Duburs, N. Sjakste
{"title":"Study of Impact of a 1,4-DHP Derivative Glutapyrone on DNA Using In Vitro Tests","authors":"E. Leonova, Kristīne Dišlere, E. Rostoka, L. Baumane, E. Bisenieks, G. Duburs, N. Sjakste","doi":"10.2478/prolas-2023-0006","DOIUrl":null,"url":null,"abstract":"Abstract The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/prolas-2023-0006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Multidisciplinary","Score":null,"Total":0}
引用次数: 1
Abstract
Abstract The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapyrone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction, it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the compound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
