Detection of telomerase RNA component in human liver tissues

International Hepatology Communications Pub Date : 1997-01-01 DOI:10.1016/S0928-4346(96)00344-1

Hisashi Hisatomi, Yoshimi Ohmura, Kumi Nagao, Naomi Mori, Emi Wada, Yasuko Kawaoto, Toshiyasu Yamauchi, Kazumasa Hikiji

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引用次数: 4

Abstract

This study investigated the relationship between telomerase activity and telomerase RNA component (telomerase RNA) in human liver tissues. Telomerase RNA was detected in all hepatocellular carcinoma (HCC) tissues ( $2020$ ), and telomerase activity was detected in 18 (90.00%) of the 20 HCC tissues. Telomerase RNA was detected in 17 (89.47%) of 19 livers with liver cirrhosis, and telomerase activity was detected in eight (42.11%) of the 19 tissues. In livers with chronic hepatitis, telomerase RNA was detected in 11 (64.71%) of 17, and telomerase activity was detected in six (35.29%) of the 17 tissues. Telomerase RNA was detected in all the tissues with telomerase activity detected, i.e. 19 HCC tissues, 17 liver cirrhosis tissues and 11 chronic hepatitis tissues. In all normal tissues (n = 3), telomerase RNA and activity were not detected. From our results, one can deduce that the production of telomerase is thought to be under the control of telomerase RNA, the possibility is great that chronic hepatitis tissues and liver cirrhosis tissues become HCC when the telomerase RNA is positive.

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人肝组织端粒酶RNA成分的检测

本研究探讨了人肝组织端粒酶活性与端粒酶RNA组分(端粒酶RNA)的关系。在所有肝细胞癌(HCC)组织中均检测到端粒酶RNA(2020)， 20例HCC组织中有18例(90.00%)检测到端粒酶活性。19例肝硬化患者肝脏中有17例(89.47%)检测到端粒酶RNA, 8例(42.11%)检测到端粒酶活性。17例慢性肝炎肝脏组织中有11例(64.71%)检测到端粒酶RNA, 6例(35.29%)检测到端粒酶活性。在所有端粒酶活性检测组织中均检测到端粒酶RNA，即19例HCC组织、17例肝硬化组织和11例慢性肝炎组织。所有正常组织(n = 3)均未检测端粒酶RNA及其活性。从我们的结果可以推断，端粒酶的产生被认为是受端粒酶RNA的控制，当端粒酶RNA呈阳性时，慢性肝炎组织和肝硬化组织成为HCC的可能性很大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Hepatology Communications

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