POTENTIAL IMPACTS OF SAGE (SALVIA OFFICINALIS L.) LEAVES EXTRACT AND XANTHOPHYLLOMYCES DENDRORHOUS CULTURAL FILTRATE ON DIMETHYLFORMAMIDE INDUCED PHYSIOLOGICAL RESPONSES AND HEMATOTOXICITY IN MICE

Abstract

The purpose of this study was to assess the potential effects of Salvia officinalis ethanolic leaves extract (SEE) and Xanthophyllomyces dendrorhous culture filtrate (XDCF) on physiological and hematological responses in mice injected interperitoneally with dimethyl formamide (DMF). Twelve groups comprised equally of 36 male and female Swiss albino mice were divided into 6 groups of males and 6 groups of females were represented (3 animals each). The experimental administrations were the same for the male and female groups. The first group was the control group. Every day for 21 days, the second, third, and fourth groups received 378 mg of DMF intraperitoneally, 100 mg of SEE orally, and 3300 µl of XDCF intraperitoneally / kg body weight, respectively. The fifth group received 100 mg of SEE / kg body weight orally every day for a further 21 days after receiving 378 mg of DMF / kg body weight intraperitoneally every day for 21 days. Following a 21-day intraperitoneally exposure to 378 mg of DMF / kg body weight per day the sixth group was given daily XDCF intraperitoneally by 3300 µl / kg body weight. In response to DMF administration,