Assessment of risk factors and angiographic profile in left main coronary artery disease: An observational study

R. Singh, A. Kandoria, P. Negi
{"title":"Assessment of risk factors and angiographic profile in left main coronary artery disease: An observational study","authors":"R. Singh, A. Kandoria, P. Negi","doi":"10.4103/cmi.cmi_127_22","DOIUrl":null,"url":null,"abstract":"Background: Diagnostic and management challenges with unpredictable angiographic presentations are encountered in left main coronary artery disease (LMCAD) patients. Therefore, this study was designed to evaluate the prevalence, risk factors, angiographic profile, and outcomes associated with LMCAD at 6-month follow-up. Materials and Methods: This was a prospective observational study where a total of 1474 patients undergoing coronary angiography were enrolled between March 2018 and August 2019. Demographic details, physical examination, and routine biochemical investigations were reported. Obstructive LMCAD patients were managed either with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) according to syntax score, and outcomes were recorded at 6-month follow-up. Results: The mean age of the overall study population (1474 patients) was 59 ± 8.1 years with male 959 (65%) preponderance. Obstructive LMCAD was observed in 103 (6%) patients. Smoking was the prime risk factor associated with obstructive LMCAD observed among 58 (56%) patients followed by hypertension in 45 (43%), dyslipidemia in 42 (40%), obesity in 26 (25%), and diabetes mellitus in 23 (22%) patients. Among 41 (40%) obstructive LMCAD patients, non-ST-elevation myocardial infarction/unstable angina was the major presentation. The majorly affected target vessels were left anterior descending artery (100%) and left circumflex artery (80%) among 103 and 83 patients, respectively. Triple-vessel disease was predominantly observed among 63 (62%) obstructive LMCAD patients. PCI and CABG were performed in 19 (18.4%) and 27 (26.2%) patients with a mean syntax score of 20 and 31, respectively. Conclusion: Smoking, advanced age, diabetes, and dyslipidemia were significantly associated risk factors of LMCAD.","PeriodicalId":72734,"journal":{"name":"Current medical issues","volume":"45 1","pages":"151 - 156"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current medical issues","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/cmi.cmi_127_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Diagnostic and management challenges with unpredictable angiographic presentations are encountered in left main coronary artery disease (LMCAD) patients. Therefore, this study was designed to evaluate the prevalence, risk factors, angiographic profile, and outcomes associated with LMCAD at 6-month follow-up. Materials and Methods: This was a prospective observational study where a total of 1474 patients undergoing coronary angiography were enrolled between March 2018 and August 2019. Demographic details, physical examination, and routine biochemical investigations were reported. Obstructive LMCAD patients were managed either with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) according to syntax score, and outcomes were recorded at 6-month follow-up. Results: The mean age of the overall study population (1474 patients) was 59 ± 8.1 years with male 959 (65%) preponderance. Obstructive LMCAD was observed in 103 (6%) patients. Smoking was the prime risk factor associated with obstructive LMCAD observed among 58 (56%) patients followed by hypertension in 45 (43%), dyslipidemia in 42 (40%), obesity in 26 (25%), and diabetes mellitus in 23 (22%) patients. Among 41 (40%) obstructive LMCAD patients, non-ST-elevation myocardial infarction/unstable angina was the major presentation. The majorly affected target vessels were left anterior descending artery (100%) and left circumflex artery (80%) among 103 and 83 patients, respectively. Triple-vessel disease was predominantly observed among 63 (62%) obstructive LMCAD patients. PCI and CABG were performed in 19 (18.4%) and 27 (26.2%) patients with a mean syntax score of 20 and 31, respectively. Conclusion: Smoking, advanced age, diabetes, and dyslipidemia were significantly associated risk factors of LMCAD.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
左主干冠状动脉疾病的危险因素和血管造影评估:一项观察性研究
背景:左主干冠状动脉疾病(LMCAD)患者的诊断和治疗面临着难以预测的血管造影表现的挑战。因此,本研究旨在评估6个月随访时LMCAD的患病率、危险因素、血管造影特征和相关结果。材料和方法:这是一项前瞻性观察研究,在2018年3月至2019年8月期间,共有1474名接受冠状动脉造影的患者入组。报告了人口统计细节、体格检查和常规生化调查。根据句法评分对梗阻性LMCAD患者进行经皮冠状动脉介入治疗(PCI)或冠状动脉旁路移植术(CABG),随访6个月记录结果。结果:总体研究人群(1474例)的平均年龄为59±8.1岁,男性959(65%)居多。103例(6%)患者出现阻塞性LMCAD。在58例(56%)患者中,吸烟是与阻塞性LMCAD相关的主要危险因素,其次是高血压45例(43%),血脂异常42例(40%),肥胖26例(25%),糖尿病23例(22%)。在41例(40%)梗阻性LMCAD患者中,非st段抬高型心肌梗死/不稳定型心绞痛是主要表现。103例患者以左前降支为主(100%),83例患者以左旋支为主(80%)。63例(62%)阻塞性LMCAD患者以三支血管病变为主。分别有19例(18.4%)和27例(26.2%)患者行PCI和CABG,平均句法评分分别为20分和31分。结论:吸烟、高龄、糖尿病、血脂异常是LMCAD的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Should Medicine be Taught in Leading Medical Languages or the Mother Tongue? Utility of Sensate Pedicled Medial Thigh Perforator Flaps in Treating Recurrent Ischial Ulcers in Individuals with Cauda Equina Lesions and Spinal Dysraphism – A Retrospective Analysis Compound Odontome Causing Agenesis of Mandibular Canine Diagnosis of Cystic Fibrosis Beyond Childhood in India Rhythm Generating Mechanisms in Rat Sinoatrial Node
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1