let-7d i miR-18a jako biomarkery w nowotworach głowy i szyi

Abstract

Head and neck squamous cell carcinomas are one of the worst prognosis cancers with high mortality of patients. The main methods of treatment are surgery, radiotherapy and chemotherapy. The improvement of currently applied therapeutic methods is seen in the use of molecular features of tumour marker that describes the behavior of cells after treatment. miRNAs are supposed to be a good diagnostic and prognostic biomarkers. They are small, non-coding RNAs which are involved in regulatory function in the cell. It has been revealed that the biogenesis and function of miRNAs are disturbed in tumour cells which results in the acquisition of specific phenotypic characteristics by tumour cells. The tumour examination in the context of miRNAs expression may allow to describe potential tumour ability to its growth, progression, radio – and chemosensitivity. Creation of the miRNA panel for the personalization of treatment is still at the research stage. In this work, we collected data concerning two miRNAs: let-7d and miR-18a. We have characterized them for potential use as miRbiomarkers.