Nano-Materials-Based Printed Glucose Sensor for Use in Incontinence Products for Health-Care Applications

IF 1.5 4区 材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY Micro & Nano Letters Pub Date : 2023-05-12 DOI:10.3390/micro3020035
M. Hubl, Raghied M. Atta, R. Kaufhold, Bei Wang, H. Ngo
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Abstract

Our recent development of a wireless humidity sensor system embedded in incontinence products enables new sensor applications to diagnose and supervise geriatric diseases (i.e., age-related diabetes mellitus type II). The measurement of glucose in urine, so-called glucosuria, is an early indicator for an incipient diabetes mellitus disease, whose symptoms are often age-related but misjudged. In this paper, an incontinence glucose sensor is printed with biocompatible ink and Prussian blue as an electron mediator on foil and functionalized with immobilized glucose oxidase. Inkjet printing of multiple layers of Nafion prevents large interference substances from diffusing into the measuring electrode and allows precise adjustment of the linear working range, which is significantly different from blood glucose measurement. Performance tests show the potential to detect minimum glucose values and store the sensor over a prolonged period at room temperature. The printed glucose sensor can be embedded into the absorber material of incontinence products, where capillary forces transport the urine analyte to the detection area. An attached readout module with an integrated potentiostat measures the glucose concentration in urine, which is transmitted wirelessly with incontinence events and stored in a cloud service for further analysis by medical staff and care workers.
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基于纳米材料的打印葡萄糖传感器用于失禁产品的医疗保健应用
我们最近开发的无线湿度传感器系统嵌入失禁产品,使新的传感器应用于诊断和监测老年性疾病(即与年龄有关的II型糖尿病)。尿液中葡萄糖的测量,即所谓的血糖,是早期糖尿病疾病的早期指标,其症状通常与年龄有关,但被误判。本文采用生物相容性墨水和普鲁士蓝作为电子介质,在箔片上印制了一种尿失禁葡萄糖传感器,并用固定化葡萄糖氧化酶进行了功能化。多层Nafion的喷墨打印防止大量干扰物质扩散到测量电极,并允许精确调整线性工作范围,这与血糖测量有明显不同。性能测试表明,该传感器具有检测最低葡萄糖值和在室温下长时间储存的潜力。打印的葡萄糖传感器可以嵌入到尿失禁产品的吸收材料中,毛细管力将尿液分析物输送到检测区域。附带的带有集成恒电位器的读出模块可测量尿液中的葡萄糖浓度,尿失禁事件会通过无线传输,并存储在云服务中,供医务人员和护理人员进一步分析。
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来源期刊
Micro & Nano Letters
Micro & Nano Letters 工程技术-材料科学:综合
CiteScore
3.30
自引率
0.00%
发文量
58
审稿时长
2.8 months
期刊介绍: Micro & Nano Letters offers express online publication of short research papers containing the latest advances in miniature and ultraminiature structures and systems. With an average of six weeks to decision, and publication online in advance of each issue, Micro & Nano Letters offers a rapid route for the international dissemination of high quality research findings from both the micro and nano communities. Scope Micro & Nano Letters offers express online publication of short research papers containing the latest advances in micro and nano-scale science, engineering and technology, with at least one dimension ranging from micrometers to nanometers. Micro & Nano Letters offers readers high-quality original research from both the micro and nano communities, and the materials and devices communities. Bridging this gap between materials science and micro and nano-scale devices, Micro & Nano Letters addresses issues in the disciplines of engineering, physical, chemical, and biological science. It places particular emphasis on cross-disciplinary activities and applications. Typical topics include: Micro and nanostructures for the device communities MEMS and NEMS Modelling, simulation and realisation of micro and nanoscale structures, devices and systems, with comparisons to experimental data Synthesis and processing Micro and nano-photonics Molecular machines, circuits and self-assembly Organic and inorganic micro and nanostructures Micro and nano-fluidics
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