Comparative Histopathologic Evaluation of the Effects of Portulaca oleracea, Omega-3, and Combination of Sodium Selenite and Vitamin E on Hepatic Enzymes of Experimental Diabetic Rats

D. Babazadeh, A. Shabestari Asl, A. Sadeghi, M. Saeed, Arman Moshavery
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Abstract

Introduction: Portulaca oleracea (PO) plant, Omega 3, and Sodium Selenite plus Vitamin E have antidiabetic effects by compensating for the deficiency in insulin release and enhancing antioxidant status. The purpose of the present study was to comparatively assess the effect of Portulaca oleracea, omega-3, and a combination of Sodium Selenite and Vitamin E on hepatic enzyme activities in streptozotocin-induced diabetic Rats. Materials and methods: A total of 48 adult male Wistar rats (weighing approximately 220 ± 10 g) were injected by a single intraperitoneal injection of streptozotocin (60 mg/kg body weight.) and were randomly assigned to 4 groups, and 4 replicates for each group. Group 1 served as diabetic control, groups 2, 3, and 4 received Portulaca oleracea extract (1.5 mg/kg/day, orally), Omega-3 (500 mg/kg/day, orally), and Sodium Selenite (0.5 mg/kg/day, orally) plus Vitamin E (400 Iu/kg/day, orally), respectively, for 28 days. At the end of the study, blood samples were taken for biochemical investigations. Results: The levels of blood glucose, AST, ALP, and GGT enzymes in all treatment groups were less than those of the control group. The ALT enzyme activity in rats treated with Portulaca oleracea and Vitamin E plus Selenium was less than in control and omega-3 treatment groups. Conclusion: Results indicated that Portulaca oleracea is more effective in hepatic enzyme activities of diabetic rats, compared to other treatment groups.
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马齿苋、Omega-3及亚硒酸钠和维生素E联合对实验性糖尿病大鼠肝酶影响的组织病理学比较
简介:马齿苋(porulaca oleracea, PO)植物、Omega - 3和亚硒酸钠加维生素E通过补偿胰岛素释放不足和增强抗氧化状态而具有抗糖尿病作用。本研究的目的是比较评估马齿苋、omega-3以及亚硒酸钠和维生素E联合使用对链脲佐菌素诱导的糖尿病大鼠肝酶活性的影响。材料与方法:选用体重约220±10 g的成年雄性Wistar大鼠48只,单次腹腔注射链脲佐菌素(60 mg/kg体重),随机分为4组,每组4个重复。1组作为糖尿病对照组,2、3、4组分别给予马齿苋提取物(1.5 mg/kg/d,口服)、Omega-3提取物(500 mg/kg/d,口服)、亚硒酸钠(0.5 mg/kg/d,口服)加维生素E (400 Iu/kg/d,口服),连用28 d。在研究结束时,采集血样进行生化检查。结果:各治疗组患者血糖、AST、ALP、GGT水平均低于对照组。马齿苋和维生素E加硒组大鼠的ALT酶活性低于对照组和omega-3组。结论:马齿苋对糖尿病大鼠肝酶活性的影响优于其他治疗组。
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期刊介绍: Each month, Advances in Small Animal Medicine and Surgery features abstracts of material from recent publications and presentations, followed by comments from specialists in the field. Small animal veterinarians and veterinary technicians gain new insight into specific topics and increase their skills in judging how to apply new tests and treatments in practice situations.
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