A dual-stimuli-responsive delivery system for poorly water-soluble drug based on iron oxide nanoparticles

IF 0.7 4区材料科学 Q4 METALLURGY & METALLURGICAL ENGINEERING International Journal of Materials Research Pub Date : 2023-08-04 DOI:10.1557/s43578-023-01120-8

Tien-Dung Nguyen-Dinh, Nhu-Thuan Nguyen-Phuoc, Ngoc Thuy Trang Le, N. H. Nguyen, D. Nguyen

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Abstract

This study aimed to prepared a dual-stimuli-responsive delivery system based on iron oxide nanoparticles (IONPs) and Pluronic F127—Folic acid conjugation (F127-FA) for poorly water-soluble drugs. Oleic acid-coated IONPs were prepared and modified with F127-FA using ultrasonic treatment to form IONPs/F127-FA meanwhile Quercetin (QCT)—a poorly water-soluble drug was encapsulated into the nano-system. The results illustrated the successful preparation of IONPs/F127-FA and its saturation magnetization value was found to be 25.6 emu/g. Moreover, QCT was effectively entrapped into the synthesized IONPs/F127-FA and showed 23.45 ± 7.23% loading capacity and 89.87 ± 2.05% entrapment efficiency. Additionally, the MTT assay revealed that loaded QCT in IONPs/F127-FA showed high inhibition against the human breast cancer cells compared to the free one, which was attributed to the ability to bind to folate receptor α of IONPs/F127-FA. These results suggested that the IONPs/F127-FA system would be a promising dual-stimuli-responsive drug delivery system in cancer treatment.

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一种基于氧化铁纳米颗粒的低水溶性药物双刺激反应递送系统

本研究旨在制备一种基于氧化铁纳米颗粒(IONPs)和Pluronic f127 -叶酸偶联物(F127-FA)的双刺激响应递送系统，用于低水溶性药物。制备了油酸包被的IONPs，并用F127-FA进行超声修饰，形成IONPs/F127-FA，同时将槲皮素(QCT)包被到纳米体系中。结果表明，成功制备了IONPs/F127-FA，其饱和磁化值为25.6 emu/g。此外，QCT有效地包埋在合成的IONPs/F127-FA中，其负载能力为23.45±7.23%，包埋效率为89.87±2.05%。此外，MTT实验显示，与游离的QCT相比，装载在IONPs/F127-FA中的QCT对人乳腺癌细胞具有较高的抑制作用，这是由于能够与IONPs/F127-FA的叶酸受体α结合。这些结果表明，IONPs/F127-FA系统将是一种很有前景的双刺激反应给药系统。

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来源期刊

International Journal of Materials Research 工程技术-冶金工程

CiteScore

1.30

自引率

12.50%

发文量

119

审稿时长

6.4 months

期刊介绍： The International Journal of Materials Research (IJMR) publishes original high quality experimental and theoretical papers and reviews on basic and applied research in the field of materials science and engineering, with focus on synthesis, processing, constitution, and properties of all classes of materials. Particular emphasis is placed on microstructural design, phase relations, computational thermodynamics, and kinetics at the nano to macro scale. Contributions may also focus on progress in advanced characterization techniques. All articles are subject to thorough, independent peer review.