Relations métaboliques entre les ribosomes libres et liés du foie de rat

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects Pub Date : 1964-09-11 DOI:10.1016/0926-6550(64)90175-6

Y Moule, G.Delhumeau De Ongay

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引用次数: 24

Abstract

The interrelationships between the free and bound ribosomes of the hepatic cell in the regenerating rat liver have been studied by an examination of the metabolic relationships between RNA's of these two kinds of particles.

The kinetics of incorporation of [¹⁴C]orotic acid show no precursor-product relationship between the RNA's of free and bound ribosomes. This means that there is no systematic derivation of one kind of particle from the other. So, it is not obligatory for the life of a newly synthesized ribosome to proceed from that of a free state to that of a membrane-bound state, or inversely.

The results do not establish, however, that the two populations are independent. Indeed, the kinetics suggest the possibility of a constant exchange between them.

In addition, a precursor-product relationship has been found between nuclear RNA and ribosomal RNA. The different results are discussed.

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大鼠肝脏中游离核糖体与结合核糖体的代谢关系

通过对再生大鼠肝细胞中游离核糖体和结合核糖体RNA的代谢关系的研究，探讨了再生大鼠肝细胞中游离核糖体和结合核糖体之间的相互关系。[14C]乳香酸的掺入动力学表明游离核糖体和结合核糖体的RNA之间没有前体-产物关系。这意味着不存在一种粒子从另一种粒子的系统推导。因此，新合成的核糖体的生命并不是必须从自由状态进入到膜结合状态，或者相反。然而，研究结果并不能证明这两个种群是独立的。事实上，动力学表明它们之间有可能不断交换。此外，核RNA和核糖体RNA之间存在前体-产物关系。讨论了不同的结果。

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Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects

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