The Role of Autophagy in Myocardial Ischemia and Reperfusion

Xueli Guo
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Abstract

hypoxia and low levels of oxidative stress, [6, 7] can promote cell survival. But excessively activated autophagy can cause cell death. [8, 9] Therefore, autophagy is considered a therapeutic target for ischemic heart disease, but the specific mechanism is still clear. [10, 11] In recent years, the role of autophagy in MI/RI has been paid more and more attention. This paper will review the role of autophagy in MI/RI.
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自噬在心肌缺血再灌注中的作用
低氧和低水平的氧化应激[6,7]可以促进细胞存活。但过度激活的自噬会导致细胞死亡。[8,9]因此,自噬被认为是缺血性心脏病的治疗靶点,但具体机制尚不清楚。[10,11]近年来,自噬在MI/RI中的作用越来越受到重视。本文将对自噬在心肌梗死/心肌梗死中的作用进行综述。
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