{"title":"The comparison of theophylline permeabilities from hydrophilic polyhydroxyethylmethacrylate and hydrophobic polyurethane, polyvinylchloride membranes","authors":"M. Pulat","doi":"10.1016/0923-1137(94)90137-6","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, the diffusion characteristics of theophylline through polyurethane (PU), polyvinylchloride (PVC) and polyhydroxyethylmethacrylate (PHEMA) membranes were investigated for their usage as oral controlled-release reservoir systems. PU and PVC membranes were prepared by the solvent-casting method and PHEMA membrane was prepared by bulk polymerization of 2-hydroxyethylmethacrylate in different thicknesses. Diffusion measurements were performed in simulated gastric fluid and simulated intestinal fluid during 10 h at 37°C using a diffusion cell. Permeability coefficients calculated from diffusion experiments were found to be approximately 10 times higher in PHEMA than PU and PVC membranes.</p></div>","PeriodicalId":20864,"journal":{"name":"Reactive Polymers","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-1137(94)90137-6","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reactive Polymers","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0923113794901376","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
In this study, the diffusion characteristics of theophylline through polyurethane (PU), polyvinylchloride (PVC) and polyhydroxyethylmethacrylate (PHEMA) membranes were investigated for their usage as oral controlled-release reservoir systems. PU and PVC membranes were prepared by the solvent-casting method and PHEMA membrane was prepared by bulk polymerization of 2-hydroxyethylmethacrylate in different thicknesses. Diffusion measurements were performed in simulated gastric fluid and simulated intestinal fluid during 10 h at 37°C using a diffusion cell. Permeability coefficients calculated from diffusion experiments were found to be approximately 10 times higher in PHEMA than PU and PVC membranes.
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