Chin-sheng Wu, Wen-Chien Chiu, Jih P. Wang, S. Kuo
{"title":"Synthesis and Biological Activity of 2,6- and 2,7-Disubstituted Anthraquinones.","authors":"Chin-sheng Wu, Wen-Chien Chiu, Jih P. Wang, S. Kuo","doi":"10.7019/CPJ.200208.0245","DOIUrl":null,"url":null,"abstract":"A series of 2, 6- and 2, 7-disubstituted anthraquinones was synthesized and evaluated for inhibition of mast cell and neutrophil degranulation as well as neutrophil superoxide formation. Among them, anthraquinone-2, 7-diearboxylie acid (10c) was the most promising agent. Compound 10c significantly inhibited the PCA reaction and histamine- and LTD4-induced skin reactions in rats.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"54 1","pages":"245-257"},"PeriodicalIF":0.0000,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Chinese Pharmaceutical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7019/CPJ.200208.0245","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
A series of 2, 6- and 2, 7-disubstituted anthraquinones was synthesized and evaluated for inhibition of mast cell and neutrophil degranulation as well as neutrophil superoxide formation. Among them, anthraquinone-2, 7-diearboxylie acid (10c) was the most promising agent. Compound 10c significantly inhibited the PCA reaction and histamine- and LTD4-induced skin reactions in rats.
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