Formulation, Optimization and Evaluation of Capecitabine Tablet for Colon Specific Drug Delivery System

Abstract

Aim: The present research is focused on development and optimization of colon specific, fast disintegrating Capecitabine tablet for the treatment of Colon cancer. Methods: Colon targeted core tablet of Capecitabine was prepared by using CCS (Croscarmellose sodium) as a super disintegrating agent by direct compression method and coating was done over the core tablets by using pectin in different ratios by compression coating method. The colon targeted coating was done on the compression coated tablets by using ES100 and CAP (Cellulose acetate phthalate) in different ratios by dip coating method. In vitro swelling studies were carried out at different pH (1.2, 6.8 and 7.4). The Design Expert software (v.10) was used to optimise the best formulation and an in vitro cumulative percentage of drug release in different dissolution media (pH 1.2, 6.8 and 7.4) with respect to the time interval (2hr, 7hr and 9hr) as dependable variable. Results: Optimized formulation of Capecitabine tablet shows satisfactory result with respect to all pre and post compression test parameters and it was significantly stable during stability studies conducted for 30and 60 days. Conclusion: From the above research it was found that, the optimised formulation of less half-life period anticancer drug Capecitabine can be properly targeted to colon area with the help of pectin and eudragit S 100.