K. Stokes, Pryscilla Yoon, M. Makiya, Meheret Gebreegziabher, Nicole C Holland-Thomas, JeanAnne M Ware, L. Wetzler, P. Khoury, A. Klion
{"title":"Mechanisms of glucocorticoid resistance in hypereosinophilic syndromes","authors":"K. Stokes, Pryscilla Yoon, M. Makiya, Meheret Gebreegziabher, Nicole C Holland-Thomas, JeanAnne M Ware, L. Wetzler, P. Khoury, A. Klion","doi":"10.1111/cea.13509","DOIUrl":null,"url":null,"abstract":"Glucocorticoids (GC) are considered first‐line therapy for most patients with hypereosinophilic syndrome (HES). Although response rates are generally high, many patients require moderate to high doses for control of eosinophilia and symptoms, and up to 15% of patients do not respond at all. Despite this, little is known about the mechanisms of GC resistance in patients with HES.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"19 1","pages":"1598 - 1604"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical & Experimental Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/cea.13509","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Glucocorticoids (GC) are considered first‐line therapy for most patients with hypereosinophilic syndrome (HES). Although response rates are generally high, many patients require moderate to high doses for control of eosinophilia and symptoms, and up to 15% of patients do not respond at all. Despite this, little is known about the mechanisms of GC resistance in patients with HES.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
