ATAD3 and endoplasmic reticulum to mitochondria connection: a main actor and interaction regarding pathogenesis

Abstract

Metabolic fluxes between mitochondria and endoplasmic reticulum appear today of first importance in normal and pathologic cellular physiology sustaining important regulation processes involved in mitochondrial biogenesis, homeostasis and stress responses. The basis of these interrelations is well described in yeast, the mechanism involved in higher eukaryotes and mammals is unknown. Here will be to present and emphasize on the role of a newly discovered protein, ATAD3, that may represent a molecular bridge between these compartments and essential link for associated exchanging processes.