{"title":"Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013","authors":"Rune Andersen Hartvig, Niels Bjerre Holm, Petur Weihe Dalsgaard, Lotte Ask Reitzel, Irene Breum Müller, K. Linnet","doi":"10.2478/sjfs-2014-0003","DOIUrl":null,"url":null,"abstract":"Abstract We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with a description of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for the peptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum sample preparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin it was necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time.","PeriodicalId":41138,"journal":{"name":"Scandinavian Journal of Forensic Science","volume":"13 1","pages":"42 - 49"},"PeriodicalIF":1.0000,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian Journal of Forensic Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/sjfs-2014-0003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, LEGAL","Score":null,"Total":0}
引用次数: 13
Abstract
Abstract We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with a description of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for the peptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum sample preparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin it was necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time.
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