Alteration in Antioxidant Defence System and Oxidative Stress in blood of Liver Cirrhosis

A. Thakkar, H. Shah, N. Patel
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Abstract

Available online at: www.isroset.org Received: 10/Jan/2019, Accepted: 11/Feb/2019, Online: 28/Feb/2019 AbstractSerum liver marker enzymes ALT, AST, ALP and GGT are generally used as liver marker enzymes however they cannot provide exact idea regarding establishment of liver disease condition because many liver cirrhotic participants indicate non-significant alteration. Present study is aimed to know the level of antioxidant defense system and oxidative stress in controls and cirrhotic participants. The cross-sectional study was carried out at tertiary centre of gastroenterologist unit at Anand. Experimental participants were divided into two groups: Control (n= 52, Age26.7±1.23 years, 39 M/ 13 F) and cirrhosis (n= 44, Age53.48±2.02 years, 34 M/10 F). All participants underwent anthropometric assessment, clinical examination, biochemical parameters, antioxidant parameters and lipid peroxidation marker or oxidative stress marker. Results of our study indicates nonconclusive increase in serum enzyme level. As an average only 42-67 % of the participants indicates increase (ALT (55%), AST (67.5%), GGT (57.5%) and ALP (42.5%)). The total antioxidant activity (Gallic acid equivalent (GAE (p<0.0001)) and Trolox equivalent (TE) (p<0.0001)) and antioxidant enzymes such as Catalase (CAT (p<0.0001)), Glutathione Peroxidase (GSHPx (p<0.0001)) and Glutathione-s-transferase (GST (p<0.0001)) were significantly decreased except superoxide dismutase (SOD (p<0.05)) during cirrhosis condition. Lipid peroxidation marker or oxidative stress marker (MDA) was significantly increased (p<0.0001) in cirrhotic participants compared to controls. The alteration in the above parameters is among all (100%) the participants. Study strongly indicates that antioxidant enzymes namely GST, GSHPx and CAT can be used as surrogate markers of oxidative stress for the cirrhosis condition.
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肝硬化患者血液中抗氧化防御系统及氧化应激的改变
摘要血清肝脏标记酶ALT、AST、ALP和GGT通常被用作肝脏标记酶,但由于许多肝硬化参与者表示没有明显改变,因此它们不能提供肝脏疾病状况的确切信息。本研究旨在了解对照组和肝硬化参与者的抗氧化防御系统和氧化应激水平。横断面研究是在阿南德胃肠病学三级中心进行的。实验参与者分为对照组(n= 52,年龄26.7±1.23岁,39 M/ 13 F)和肝硬化组(n= 44,年龄53.48±2.02岁,34 M/10 F)。所有参与者均进行了人体测量、临床检查、生化指标、抗氧化指标和脂质过氧化指标或氧化应激指标。我们的研究结果表明血清酶水平的增加不是决定性的。平均只有42- 67%的参与者表示ALT(55%)、AST(67.5%)、GGT(57.5%)和ALP(42.5%)升高。总抗氧化活性(没食子酸等效(GAE (p<0.0001))和Trolox等效(TE) (p<0.0001))以及过氧化氢酶(CAT (p<0.0001))、谷胱甘肽过氧化物酶(GSHPx (p<0.0001))和谷胱甘肽s-转移酶(GST (p<0.0001))等抗氧化酶(除超氧化物歧化酶(SOD (p<0.05))外)均显著降低。与对照组相比,肝硬化参与者的脂质过氧化标志物或氧化应激标志物(MDA)显著升高(p<0.0001)。以上参数的改变是所有(100%)参与者的。研究强烈提示抗氧化酶GST、GSHPx和CAT可以作为肝硬化氧化应激的替代指标。
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