Combined Effects of Ethylacetate Extracts of Propolis Inducing Cell Death of Human Colorectal Adenocarcinoma Cells

Abstract

Since antiquity, propolis has been said to show anti-cancerous effects in the treatment of human breast cancer cells or human colorectal carcinoma cells, all in connection with alterations in the apoptosis pathways. At the same time, therapeutics like D, L-methadone have shown success in amendments of such pathways, being associated with changes in cancer cell morphology and at the same time, serving as a beneficial analgesic during chemotherapy. Using ethylacetate extracts of wax-free Bio99T M propolis tincture, which is exclusively distributed by our commercial partners, we showed a combination of those effects in an, both of apoptotic and analgesic nature, with a success outcompeting prevailing chemotherapeutic procedures in the treatment of human colorectal adenocarcinoma cells. We therefore suggest a reconsideration of the prevail of common cancer treatments and instead, focusing on the research on natural alternatives in the form of propolis extracts.