{"title":"Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases","authors":"G. Mallikarjun, A. Raju, J. Yadav","doi":"10.56042/ijcb.v60i11.54954","DOIUrl":null,"url":null,"abstract":"A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1 H and 13 C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d , 12g and 12l demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5 µg/mL. Further, compounds 12d , 12g and 12l exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5 µg/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.56042/ijcb.v60i11.54954","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1 H and 13 C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d , 12g and 12l demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5 µg/mL. Further, compounds 12d , 12g and 12l exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5 µg/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.
期刊介绍：
Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".
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