Modification in the Approach of Developing Solid Dispersed Particles for Enhanced Dissolution

Abstract

Objective: To use tween 80 with a novel approach of applying a layer over the outer surface of solid dispersion particles for the improvement of the poor results of solubility enhancement by solid dispersion produced by the conventional technique of using surfactant in the matrix form. Methods: The solid dispersed particles of Repaglinide and Polyvinylpyrrolidone K30 were formulated using solvent evaporation method. The surfactant tween 80 was added as matrix forming agent during the solid dispersion and the prepared solid dispersed particles were also allowed to coat with tween 80 just by applying over the surface of container in which solvent was allowed to evaporate. Key findings: It was inferred that tween 80 coated particles were formulated with maximum solubility enhancement of 1982 μg/ml as compared to 103 μg/ml of non coated solid dispersed particles and to 3.82 μg/ml of Repaglinide. The conversion of the crystalline form of drug into an amorphous form was confirmed by DSC, X-RD, FT-IR studies and SEM images. The dissolution study showed that 90% of drug released within 30 min of dissolution. Conclusion: The solubility estimation data confirmed the efficiency of novel approach used for the formulation of particles as the best technique for solubility enhancement over conventional techniques.