А. С. Доронькина, И. П. Жаворонок, В. Г. Богдан, A. S. Doronkina, I. P. Zhavoronok, Vasily G. Bogdan
{"title":"Profile of pro- and anti-inflammatory cytokines during injection of fatty acid amides with ethanolamine and glycine in modeling peripheral neuropathy","authors":"А. С. Доронькина, И. П. Жаворонок, В. Г. Богдан, A. S. Doronkina, I. P. Zhavoronok, Vasily G. Bogdan","doi":"10.29235/1814-6023-2023-20-3-183-190","DOIUrl":null,"url":null,"abstract":"The effect of fatty acid amides during the blockade of membrane orphan GPR18, GPR55 and nuclear PPARα receptors on the level of pro- and anti-inflammatory cytokines in rats with experimental peripheral neuropathy was studied. It has been proven that the anti-inflammatory action of PEA and SEA in experimental animals with neuropathy is carried out through nuclear PPARα receptors. However, PGlyA has no anti-inflamatory effects in a rat model of peripheral neuropathy.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"109 2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the National Academy of Sciences of Belarus, Medical series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29235/1814-6023-2023-20-3-183-190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The effect of fatty acid amides during the blockade of membrane orphan GPR18, GPR55 and nuclear PPARα receptors on the level of pro- and anti-inflammatory cytokines in rats with experimental peripheral neuropathy was studied. It has been proven that the anti-inflammatory action of PEA and SEA in experimental animals with neuropathy is carried out through nuclear PPARα receptors. However, PGlyA has no anti-inflamatory effects in a rat model of peripheral neuropathy.