Synthesis, spectral characterization and antimicrobial evaluation of some novel N-allyl-2,6-diarylpiperidone O-allyl oximes

Abstract

A new series of 1-allyl-2,6-diarylpiperidone $O$-allyl oximes 13–18 were synthesized from 2,6-diarylpiperidones through various steps. The structures of all the compounds are characterized by their IR, NMR, (1D & 2D NMR) and mass spectral studies. Based on the spectral values and coupling constants all the compounds exist in chair conformation except 18 in boat conformation. Also, all the synthesized compounds are screened for their antimicrobial activity against several bacterial and fungal strains. p-Chloro-2,6-diphenyl substituted compound 15, showed remarkable activity against A.niger and compound 17 against Pseudomonas and A.flavus strains.