Effects of Diazepam/Propofol and Diazepam/Remifentanil Induction Protocols on the Coagulation in Dogs

Abstract

DOI : 10.26650/actavet.2019.434600 Studying the effect of general anaesthesia on blood parameters is extremely important both in terms of patient safety and determining protocol suitability for the patient. There is no study on the assessment of the effects of Diazepam/Propofol and Diazepam/Remifentanil combination administered to dogs on clotting time, thrombin time (TT), prothrombin time (PT), active partial thromboplastin time (aPTT) and buccal mucosa bleeding time (BMBT). The purpose of the study presented is to investigate the effects of Diazepam/Propofol and Diazepam/Remifentanil combinations on coagulation parameters in dogs aged 5 years and older, requiring surgery for various reasons. Prior to anaesthesia (T0), it was found that there was no difference between the two groups in terms of PT, TT, aPTT and BMBT (p=0.426 p=0.091, p=0.166, p=0.686, p=0.209, respectively). Following anaesthesia (T1), it was found that the buccal mucosal bleeding time in dogs in the Diazepam/Remifentanil group had a tendency to be shorter (p=0.084) than those in the Diazepam/Propofol group. Also, PT in the Diazepam/Remifentanil group was longer (p=0.031) compared to the Diazepam/Propofol group. No significant difference was found between the groups with respect to clotting time, TT or aPTT (p=0.191, p=0.467, p=0.972). While it is stated that neuroleptanalgesia produces reliable anaesthesia induction in unwell patients, based on the data obtained at the end of the study, it was determined that Diazepam/Propofol combination is more reliable in the anaesthesia of patients requiring surgical intervention.