Identifying and Preventing Cardiac Risk Factors from Fetal Life

L. Benedict, Deeksha Sarma, A. Moulick, Randy M Stevens, V. Mahan, Pa, Philadelphia, blockquote
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引用次数: 1

Abstract

Cardiac risk factors in childhood are often overlooked in clinical practice, however cardiac risk factors can start before the child is even born. Maternal factors including diet, genetics, and smoking during gestation can all impact the long-term cardiac health of the offspring. Atherosclerosis starts as early as fetal life and can continue to develop in children with risks including high cholesterol. Current guidelines for screening of cholesterol in children, while improving in recent years, still allows years of damage to accumulate before identifying those at risk. Additionally, intervention for cholesterol and other known risks in children and adolescents are often avoided or started later than necessary for optimal cardiac health. Non-pharmacological approaches like diet and exercise for cholesterol and health management can be implemented very early in life, while many pharmacological options are approved for use in certain conditions as early as ages 8 to 10. Combating cardiac disease reaching endemic levels in the developed world will take an aggressive approach in management starting with identification early in life and utilizing the appropriate tools available, both medical and lifestyle.
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识别和预防胎儿生命中的心脏危险因素
儿童时期的心脏危险因素在临床实践中经常被忽视,然而心脏危险因素可能在孩子出生前就开始了。母亲的因素包括饮食、遗传和怀孕期间吸烟都会影响后代的长期心脏健康。动脉粥样硬化早在胎儿时期就开始了,并可能在有高胆固醇等风险的儿童中继续发展。目前针对儿童胆固醇筛查的指导方针虽然近年来有所改善,但在识别出那些有风险的人之前,仍然允许多年的损害累积。此外,对儿童和青少年的胆固醇和其他已知风险的干预往往是避免的,或者开始的时间比最佳心脏健康所需的时间晚。非药物方法,如饮食和运动对胆固醇和健康管理的影响,可以在生命的早期实施,而许多药物选择被批准用于早在8到10岁的特定条件下。与发达国家达到地方病水平的心脏病作斗争,将采取积极的管理方法,从生命早期识别开始,并利用现有的适当医疗和生活方式工具。
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