The Influence of the Molecular Weight of Poly(Ethylene Oxide) on the Hydrolytic Degradation and Physical Properties of Polycaprolactone Binary Blends

Macromol Pub Date : 2023-07-03 DOI:10.3390/macromol3030026
Maurice Brendan Dalton, F. Ebrahimi, Han Xu, Ke Gong, G. Fehrenbach, E. Fuenmayor, E. Murphy, I. Major
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引用次数: 2

Abstract

The use of biodegradable polymers in tissue engineering has been widely researched due to their ability to degrade and release their components in a controlled manner, allowing for the potential regeneration of tissues. Melt blending is a common method for controlling the degradation rate of these polymers, which involves combining these materials in a molten state to create a homogenous mixture with tailored properties. In this study, polycaprolactone (PCL) was melt blended with hydrophilic poly (ethylene oxide) (PEO) of different molecular weights to assess its effect on PCL material performance. Hydrolytic degradation, thermal and viscoelastic properties, and surface hydrophilicity were performed to contrast the properties of the blends. DSC, DMA, and FTIR were performed on selected degraded PCL/PEO specimens following mass loss studies. The results showed that adding PEO to PCL reduced its melt viscosity-torque and melt temperature while increasing its hydrophilicity, optimizing PCL/PEO blend for soft tissue engineering applications and could contribute to the development of more effective and biocompatible materials for soft tissue regeneration.
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聚环氧乙烷分子量对聚己内酯二元共混物水解降解及物理性能的影响
生物可降解聚合物在组织工程中的应用已经得到了广泛的研究,因为它们能够以可控的方式降解和释放它们的成分,从而允许组织的潜在再生。熔融混合是控制这些聚合物降解率的常用方法,该方法涉及将这些材料在熔融状态下结合,以创建具有定制性能的均匀混合物。本研究将聚己内酯(PCL)与不同分子量的亲水性聚环氧乙烷(PEO)熔融共混,考察其对PCL材料性能的影响。对共混物的水解降解性能、热、粘弹性性能和表面亲水性进行了比较。在质量损失研究之后,对选择的降解PCL/PEO样品进行DSC, DMA和FTIR。结果表明,在PCL中添加PEO可降低PCL的熔体粘度-扭矩和熔体温度,同时提高其亲水性,优化PCL/PEO共混物的软组织工程应用,有助于开发更有效和生物相容性更好的软组织再生材料。
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