Eficacia y seguridad del uso de solución de superoxidación en la prevención de infecciones relacionadas con diálisis

Abstract

Introduction

In Mexico, peritoneal dialysis (PD) is the most widely used dialysis method (60%). Infections of the peritoneum, exit site, and catheter tunnel are frequent, which impairs patients’ quality of life, increases investment costs, shortens the time dialysis can be used, and often requires a switch of dialysis modality. The aim of this study was to evaluate the efficacy and safety of a superoxidized solution (Microdacyn^®) in reducing the frequency of dialysis-associated infections.

Materials and methods

We performed a controlled clinical trial with random allocation. Iodine solution was used in group I (GI) and superoxidized solution in group II (GII). We included incident patients undergoing PD without prior antibiotic therapy. We identified demographic variables, the time of occurrence of the first episode of infection, the clinical characteristics of the infectious process, the causative organisms, and clinical response.

Results

A total of 111 patients were included, 55% men and 45% women, with a mean age of 60.2 years (range: 18-90; SD 14.8), (P>.5). There were 57 patients in GI and 54 in GII. The primary causes of renal failure were diabetes mellitus, hypertension, chronic glomerulonephritis, and polycystic kidney disease (P>.5). None of the patients received antimicrobial prophylaxis at the time of peritoneal catheter placement. After 8 weeks of follow-up of intermittent PD, 14 infectious events (24.5%), 11 exit site infections (19.3%), and 3 tunnel infections (5.3%) were observed in GI, and 3 exit site infections (6%) were observed in GII (P<.05).

Conclusions

Treatment with superoxidized solution had good efficacy and safety in the prevention of PD-related infections.