Mild Hypoxia Postconditioning Induces Hypoxia-Inducible Factor 1 Alpha Expression and Improves the Neurobehavioral Abilities of Rats with Hypoxic-Ischemic Brain Damage

IF 0.4 4区 医学 Q4 PEDIATRICS Iranian Journal of Pediatrics Pub Date : 2023-08-26 DOI:10.5812/ijp-135268
Qingqing Deng, Yanqun Chang, Xiao-min Cheng, Yan Li, Xingang Luo, Xiaoyuan Tang
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Abstract

Background: While severe hypoxia is known to contribute to neurotoxicity and lead to abnormal behavior, mild hypoxia may have beneficial effects mediated through endogenous adaptive responses. Objectives: The present study aimed to investigate the effects of mild hypoxia postconditioning and long-term neurobehavioral ability rehabilitation after hypoxic-ischemic brain damage (HIBD). Methods: Seven-day-old rats underwent left carotid ligation followed by 2 hours of hypoxia stress. Rats received different protocols of mild hypoxia postconditioning for 5 days and underwent neurobehavioral testing during the last week of the study. Hypoxia-inducible factor 1 alpha (HIF-1a) expression was assessed, and neurobehavioral ability assays were performed. Results: Compared with the HIBD group, rats postconditioning with mild hypoxia showed increased HIF-1a expression, and their brain functions were better in neurobehavioral analyses. The rehabilitation of brain functions may be associated with high HIF-1a expression and better behavioral performance. Conclusions: Our findings indicate that mild hypoxia postconditioning improves neurobehavioral ability, and HIF-1a may be a potential mediator of the observed effects. Our findings suggest that there may be clinical implications for treating infants with HIBD.
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轻度缺氧后处理诱导缺氧诱导因子1 α表达,改善缺氧缺血性脑损伤大鼠神经行为能力
背景:重度缺氧可导致神经毒性并导致异常行为,而轻度缺氧可能通过内源性适应性反应介导有益作用。目的:探讨缺氧缺血性脑损伤(HIBD)后轻度缺氧后适应和长期神经行为能力康复的作用。方法:7日龄大鼠行左颈动脉结扎术后2小时缺氧应激。大鼠接受不同方案的轻度缺氧后适应5天,并在研究的最后一周进行神经行为测试。评估缺氧诱导因子1 α (HIF-1a)的表达,并进行神经行为能力测定。结果:与HIBD组相比,轻度缺氧后适应大鼠HIF-1a表达增加,脑功能在神经行为分析中表现更好。脑功能的恢复可能与HIF-1a的高表达和更好的行为表现有关。结论:我们的研究结果表明,轻度缺氧后适应可以改善神经行为能力,HIF-1a可能是观察到的效应的潜在中介。我们的研究结果表明,治疗婴儿HIBD可能具有临床意义。
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来源期刊
CiteScore
0.90
自引率
20.00%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.
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