Is There Evidence that Amylcinnamic Aldehyde Causes Allergic Contact Dermatitis?

J. Hostynek,
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引用次数: 6

Abstract

The fragrance material amylcinnamic aldehyde (ACA) has been cited as a frequent cause of allergic contact dermatitis (ACD). A review of the literature shows that when the underlying clinical and experimental data are analyzed, a clear cause-effect relationship has infrequently or rarely been established. On the basis of the generally weak sensitizing potential of this substance coupled with its generally low exposure conditions, the prevalence of clinical cases would not be expected to be particularly high. This is not to say that ACA is a frequent inducer of low-intensity but subclinical, type IV allergy in members of the public. It remains to be seen however, how often such allergy, once established, is responsible for any of the cases of ACD commonly ascribed in the literature. Indeed, in some cases, patch test conditions may not be optimal for differentiating between clinically relevant and irrelevant allergy to ACA.
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有证据表明肉桂醛会引起过敏性接触性皮炎吗?
芳香物质淀粉肉桂醛(ACA)被认为是过敏性接触性皮炎(ACD)的常见原因。对文献的回顾表明,当分析潜在的临床和实验数据时,很少或很少建立明确的因果关系。鉴于该物质的致敏潜力普遍较弱,再加上其暴露条件普遍较低,预计临床病例的发生率不会特别高。这并不是说ACA是公众中低强度但亚临床的IV型过敏的常见诱因。然而,这种过敏一旦确定,在文献中通常被认为是ACD病例的原因,其频率还有待观察。事实上,在某些情况下,斑贴试验条件可能不是鉴别ACA临床相关和不相关过敏的最佳方法。
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Acknowledgement to Referees for Exogenous Dermatology 2004 Contents Vol. 3, 2004 Author Index Vol. 3, 2004 Is There Evidence that Geraniol Causes Allergic Contact Dermatitis? Subject Index Vol. 3, 2004
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