Adrian H Chester, Mohamed Amrani, Camilla A Sproson, Magdi H Yacoub
{"title":"Interaction between thromboxane A2 and 5-hydroxytryptamine in the radial artery compared to the internal thoracic artery","authors":"Adrian H Chester, Mohamed Amrani, Camilla A Sproson, Magdi H Yacoub","doi":"10.1016/S0306-3623(01)00098-2","DOIUrl":null,"url":null,"abstract":"<div><p>The aim of the present study was to investigate if the function of 5-hydroxytryptamine-1B/1D (5-HT<sub>1B/1D</sub>) receptors in human radial artery (RA) and internal thoracic artery (ITA) can be modified by thromboxane A<sub>2</sub> (TXA<sub>2</sub>) released from the vessel wall in these two arteries that are commonly used in coronary artery bypass grafts. The 5-HT<sub>1B/1D</sub> agonist sumatriptan contracted the RA with a maximum response of 23.5±6.8 mN and a p<em>D</em><sub>2</sub> value of 6.6±0.1. The effect of sumatriptan was significantly reduced in the ITA with a maximum of 5.8±2.7 mN (<em>P</em><.05) and a p<em>D</em><sub>2</sub> value of 6.4±0.2. The TXA<sub>2</sub> receptor antagonist SQ30741 inhibited contractions to sumatriptan in the RA but not in the ITA. It is concluded that the effect mediated by 5-HT<sub>1B/1D</sub> is augmented by endogenous TXA<sub>2</sub> in the RA.</p></div>","PeriodicalId":12607,"journal":{"name":"General Pharmacology-the Vascular System","volume":"35 2","pages":"Pages 89-93"},"PeriodicalIF":0.0000,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0306-3623(01)00098-2","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General Pharmacology-the Vascular System","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306362301000982","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
The aim of the present study was to investigate if the function of 5-hydroxytryptamine-1B/1D (5-HT1B/1D) receptors in human radial artery (RA) and internal thoracic artery (ITA) can be modified by thromboxane A2 (TXA2) released from the vessel wall in these two arteries that are commonly used in coronary artery bypass grafts. The 5-HT1B/1D agonist sumatriptan contracted the RA with a maximum response of 23.5±6.8 mN and a pD2 value of 6.6±0.1. The effect of sumatriptan was significantly reduced in the ITA with a maximum of 5.8±2.7 mN (P<.05) and a pD2 value of 6.4±0.2. The TXA2 receptor antagonist SQ30741 inhibited contractions to sumatriptan in the RA but not in the ITA. It is concluded that the effect mediated by 5-HT1B/1D is augmented by endogenous TXA2 in the RA.
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