A. F. Pulungan, Debi Dinha Octora Sitepu, D. M. Sinaga
{"title":"FORMULATION OF OINTMENT OF ANTIBACTERY ETHANOL EXTRACT OF TORCH GINGER (Etlingera elatior) AGAINST BACTERIA Staphylococcus aureus","authors":"A. F. Pulungan, Debi Dinha Octora Sitepu, D. M. Sinaga","doi":"10.36656/jpfh.v1i1.30","DOIUrl":null,"url":null,"abstract":"One of the causes of infection was bacteria, such as Staphylococcus aureus. Torch ginger has been widely used to treat dwaseases caused by bacteria. Torch ginger has been studied to have antibacterial activity against Staphylococcus aureus bacteria. The purpose of thwas study was to formulate an ointment preparation of ethanol extract of torch ginger and to see if the ointment preparations had antibacterial activity against Staphylococcus aureus bacteria. The research method used in thwas research was experimental True, covering the stages: making of ethanol extract of kecombrang flower with maceration method using 96% ethanol solvent, ointment formulation made with ointment base: vaseline, adeps lanae, and propylene glycol. Made in three concentrations of extracts namely: F I with 100 mg, F II with 200 mg, and F III with 300 mg. Furthermore, the evaluation of the preparation of evaluation of physical stability and homogeneity, and test of antibacterial activity against Staphylococcus aureus bacteria with diffusion method to use Kirby odor dwasc paper. The results showed that the ointment had good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial activity test of the ointment shows that the inhibitory diameter F I has an average of 16.45 mm, F II has an average of 18.60 mm and F III has an average of 21.12 mm. Based on the results obtained it can be concluded that the preparation of the ethanol extract of torch ginger has an inhibitory power to Staphylococcus aureus bacteria. In the next research was expected to pay attention to the growing area of torch ginger and to compare the antibacterial activity between petal flowers and flower seeds using Staphylococcus aureus bacteria.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"156 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Penelitian Farmasi & Herbal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36656/jpfh.v1i1.30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
One of the causes of infection was bacteria, such as Staphylococcus aureus. Torch ginger has been widely used to treat dwaseases caused by bacteria. Torch ginger has been studied to have antibacterial activity against Staphylococcus aureus bacteria. The purpose of thwas study was to formulate an ointment preparation of ethanol extract of torch ginger and to see if the ointment preparations had antibacterial activity against Staphylococcus aureus bacteria. The research method used in thwas research was experimental True, covering the stages: making of ethanol extract of kecombrang flower with maceration method using 96% ethanol solvent, ointment formulation made with ointment base: vaseline, adeps lanae, and propylene glycol. Made in three concentrations of extracts namely: F I with 100 mg, F II with 200 mg, and F III with 300 mg. Furthermore, the evaluation of the preparation of evaluation of physical stability and homogeneity, and test of antibacterial activity against Staphylococcus aureus bacteria with diffusion method to use Kirby odor dwasc paper. The results showed that the ointment had good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial activity test of the ointment shows that the inhibitory diameter F I has an average of 16.45 mm, F II has an average of 18.60 mm and F III has an average of 21.12 mm. Based on the results obtained it can be concluded that the preparation of the ethanol extract of torch ginger has an inhibitory power to Staphylococcus aureus bacteria. In the next research was expected to pay attention to the growing area of torch ginger and to compare the antibacterial activity between petal flowers and flower seeds using Staphylococcus aureus bacteria.
感染的原因之一是细菌,如金黄色葡萄球菌。火炬姜已被广泛用于治疗由细菌引起的疾病。研究了火炬姜对金黄色葡萄球菌的抑菌活性。本研究的目的是研制火把姜乙醇提取物软膏制剂,并观察该软膏制剂对金黄色葡萄球菌的抗菌活性。本研究采用的研究方法为实验方法,包括以96%乙醇为溶剂浸渍法制备红竹花乙醇提取物,以凡士林、阿普斯兰、丙二醇为软膏基质配制软膏。由三种浓度的提取物制成,即:F I 100毫克,F II 200毫克,F III 300毫克。进一步对制备的物理性稳定性和均匀性进行评价,并采用扩散法对Kirby异味纸进行了对金黄色葡萄球菌的抑菌活性测试。结果表明,该软膏在室温下保存30 d,具有良好的物理稳定性和均匀性。抗菌活性试验表明,该软膏的抑菌直径F I平均为16.45 mm, F II平均为18.60 mm, F III平均为21.12 mm。实验结果表明,火把姜乙醇提取物的制备对金黄色葡萄球菌具有一定的抑制作用。在接下来的研究中,希望关注火炬姜的生长区域,并利用金黄色葡萄球菌比较花瓣花和花种子的抑菌活性。