Merck & Co. Licenses Exelixis’ PI3K-Delta R&D Programme

Heather Cartwright
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Abstract

In a potential US$251 M deal, Exelixis has granted Merck & Co. worldwide rights to its preclinical PI3K-delta R&D programme, including XL499, the programme’s lead compound that has potential in the treatment of rheumatoid arthritis, allergic asthma and haematological malignancies. Merck will be solely responsible for the research, development and commercialisation of compounds originating from the programme. The agreement will provide Exelixis with resources to continue the development of its most advanced compound, cabozantinib, which is in Phase III development for medullary thyroid cancer.
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默克公司授权Exelixis的PI3K-Delta研发项目
Exelixis已向默克公司授予其PI3K-delta临床前研发项目的全球权利,其中包括XL499。XL499是该项目的主导化合物,具有治疗类风湿性关节炎、过敏性哮喘和血液恶性肿瘤的潜力。默克公司将全权负责该项目中化合物的研究、开发和商业化。该协议将为Exelixis提供资源,继续开发其最先进的药物cabozantinib,该药物目前处于III期开发阶段,用于治疗甲状腺样癌。
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