The endocannabinoid system: from the receptors to therapy

Bába László-István, Kolcsár Melinda, Hack Beatrix, Gáll Zsolt, K. Zoltán
{"title":"The endocannabinoid system: from the receptors to therapy","authors":"Bába László-István, Kolcsár Melinda, Hack Beatrix, Gáll Zsolt, K. Zoltán","doi":"10.2478/orvtudert-2019-0002","DOIUrl":null,"url":null,"abstract":"Abstract The endocannabinoid system (ECS) received a lot of attention ever since its discovery. Advancements of the last three decades have shown that there are numerous mechanisms by which the ECS regulates the energy metabolism. These can either be central (regulating appetite and calorie expenditure) or peripheral (adipocyte-specific and other) mechanisms. The current review highlights some of the most important observations leading to the discovery of the ECS first, followed by a part detailing the synthesis and transport of these mediators, the receptor types and second messenger systems involved. The next part is dedicated to the mechanisms by which this system regulates the energy metabolism. Lastly, the drugs that reached the clinical phase and the main targets and strategies for future drug development will be reviewed.","PeriodicalId":9334,"journal":{"name":"Bulletin of Medical Sciences","volume":"410 1","pages":"1 - 14"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/orvtudert-2019-0002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract The endocannabinoid system (ECS) received a lot of attention ever since its discovery. Advancements of the last three decades have shown that there are numerous mechanisms by which the ECS regulates the energy metabolism. These can either be central (regulating appetite and calorie expenditure) or peripheral (adipocyte-specific and other) mechanisms. The current review highlights some of the most important observations leading to the discovery of the ECS first, followed by a part detailing the synthesis and transport of these mediators, the receptor types and second messenger systems involved. The next part is dedicated to the mechanisms by which this system regulates the energy metabolism. Lastly, the drugs that reached the clinical phase and the main targets and strategies for future drug development will be reviewed.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
内源性大麻素系统:从受体到治疗
摘要内源性大麻素系统(endocannabinoid system, ECS)自被发现以来就备受关注。近三十年来的研究进展表明,ECS调节能量代谢的机制多种多样。这些机制可以是中枢机制(调节食欲和卡路里消耗),也可以是外围机制(脂肪细胞特异性和其他)。目前的综述首先强调了导致发现ECS的一些最重要的观察结果,然后详细介绍了这些介质的合成和运输,受体类型和所涉及的第二信使系统。下一部分将专门介绍该系统调节能量代谢的机制。最后,对已进入临床阶段的药物以及未来药物开发的主要靶点和策略进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Quality by design-based method development for the determination of related substances of ezetimibe by high performance liquid chromatography Determination of the sun protection factor of sunscreens Alzheimer’s disease beyond the amyloid accumulation Radioactive background radiation measurement in Mureş county Study of pulmonary complications in patients referred to the intensive care unit
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1