A phase II, open-label clinical trial on the combination therapy with medium-chain triglycerides and ghrelin in patients with chronic obstructive pulmonary disease.

IF 0.5 4区农林科学 Q4 HORTICULTURE Fruits Pub Date : 2019-11-01 Epub Date: 2019-10-08 DOI:10.1007/s12576-019-00716-2

Keisuke Miki, Seigo Kitada, Mari Miki, Shu-Ping Hui, Rojeet Shrestha, Kenji Yoshimura, Kazuyuki Tsujino, Hiroyuki Kagawa, Yohei Oshitani, Hiroshi Kida, Ryoji Maekura, Kenji Kangawa

{"title":"A phase II, open-label clinical trial on the combination therapy with medium-chain triglycerides and ghrelin in patients with chronic obstructive pulmonary disease.","authors":"Keisuke Miki, Seigo Kitada, Mari Miki, Shu-Ping Hui, Rojeet Shrestha, Kenji Yoshimura, Kazuyuki Tsujino, Hiroyuki Kagawa, Yohei Oshitani, Hiroshi Kida, Ryoji Maekura, Kenji Kangawa","doi":"10.1007/s12576-019-00716-2","DOIUrl":null,"url":null,"abstract":"The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with edible MCT. Sequentially, 10 patients received a 3-week combination treatment with MCT and intravenous acyl ghrelin. Five-day MCT treatment increased endogenous acyl ghrelin (p = 0.0049), but the total ghrelin level was unchanged. MCT-ghrelin combination treatment improved the peak oxygen uptake (p = 0.0120) during whole treatment course. This effect was attributed to the resultant improvements in cardiac function by O2 pulse, and to the difference between inspired and expired oxygen concentration rather than minute ventilation. Addition of dietary MCT to ghrelin treatment improved the aerobic capacity of underweight COPD patients, likely by mechanisms of increased O2 delivery through improvements in primary cardiocirculatory and muscular crosstalk.","PeriodicalId":12492,"journal":{"name":"Fruits","volume":"69 1","pages":"969-979"},"PeriodicalIF":0.5000,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716959/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fruits","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1007/s12576-019-00716-2","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/10/8 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"HORTICULTURE","Score":null,"Total":0}

引用次数: 0

Abstract

The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with edible MCT. Sequentially, 10 patients received a 3-week combination treatment with MCT and intravenous acyl ghrelin. Five-day MCT treatment increased endogenous acyl ghrelin (p = 0.0049), but the total ghrelin level was unchanged. MCT-ghrelin combination treatment improved the peak oxygen uptake (p = 0.0120) during whole treatment course. This effect was attributed to the resultant improvements in cardiac function by O₂ pulse, and to the difference between inspired and expired oxygen concentration rather than minute ventilation. Addition of dietary MCT to ghrelin treatment improved the aerobic capacity of underweight COPD patients, likely by mechanisms of increased O₂ delivery through improvements in primary cardiocirculatory and muscular crosstalk.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

一项关于慢性阻塞性肺病患者接受中链甘油三酯和胃泌素联合疗法的 II 期开放标签临床试验。

本研究的目的是探讨通过膳食辛酸或中链甘油三酯（MCT）激活胃泌素对体重不足的慢性阻塞性肺病（COPD）患者的影响。11 名重度和极重度慢性阻塞性肺病患者接受了为期 5 天的食用中链甘油三酯治疗。随后，10 名患者接受了为期 3 周的 MCT 和静脉注射酰胃泌素联合治疗。为期五天的 MCT 治疗增加了内源性酰基胃泌素（p = 0.0049），但总胃泌素水平没有变化。在整个治疗过程中，MCT-胃泌素联合疗法提高了峰值摄氧量（p = 0.0120）。这一效果归因于氧气脉冲对心脏功能的改善，以及吸入氧浓度和呼出氧浓度之间的差异，而不是分钟通气量。在胃泌素治疗中添加饮食 MCT 可提高体重不足的慢性阻塞性肺病患者的有氧能力，其机制可能是通过改善原发性心循环系统和肌肉串联来增加氧气输送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Fruits HORTICULTURE-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The scope of Fruits - the International Journal of Tropical and Subtropical Horticulture includes:Fruits - The International Journal of Tropical and Subtropical Horticulture -crop production and cropping systems, -breeding, -genetics and -the release of genetic material adapted to tropical and subtropical environments, management, -storage and market supply of underutilized crops, -integrated management of pests and diseases, -clinical relevant effect of tropical and subtropical horticultural species, -peri-urban and urban tropical crop production, -sustainable water and input use, -capacity building in horticulture, -value chain development in developing countries, -seed science and agricultural engineering. Fruits, The International Journal of Tropical and Subtropical Horticulture, deals with such crops as vegetables, fruits, spices, ornamentals and medicinal plants growing in the tropical and subtropical environment.