Nanoclay-reinforced alginate/salecan composite inks for 3D printing applications

IF 6.8 3区 医学 Q1 ENGINEERING, BIOMEDICAL International Journal of Bioprinting Pub Date : 2023-07-27 DOI:10.36922/ijb.0967
R. Ianchiș, Maria Minodora Marin, Rebeca Leu Alexa, Ioana Catalina Gifu, E. Alexandrescu, G. Pîrcălăbioru, George Mihail Vlasceanu, George Mihail Teodorescu, A. Serafim, S. Preda, Cristina Lavinia Nistor, C. Petcu
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Abstract

The main objective of the present work was to produce three-dimensional (3D)- printable nanocomposite hydrogels based on two kinds of marine-sourced polysaccharides doped with nanoclay with potential biomedical application. First part of the research study investigated the preparation of the polysaccharide bicomponent hydrogel formulations followed by the selection of the optimal ratio of polysaccharides concentrations which ensured proper morphostructural stability of the 3D-printed constructs. Second step aimed to generate 3D scaffolds with high printing fidelity by modulating the nanoclay amount doped within the previously selected biopolymer ink. In compliance with the additive manufacturing experiments, the alginate–salecan hydrogels enriched with the highest nanofiller concentrations demonstrated the highest suitability for 3D printing process. The morphological and structural studies confirmed the ability of the nanocomposite formulations to efficiently produce porous 3D-printed constructs with improved fidelity. The morphostructural findings underlined the implication of choosing the appropriate ratio between components, as they have a considerable impact on the functionality of printing formulations and subsequent 3D-printed structures. Hence, from the obtained results, these novel hydrogel nanocomposites inks are considered valuable biomaterials with suitable features for applications in the additive manufacturing of 3D structures with precise shape for customized regenerative therapy.  
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纳米粘土增强海藻酸盐/salecan复合油墨用于3D打印应用
本工作的主要目的是制备三维(3D)可打印的纳米复合水凝胶,其基础是两种海洋多糖掺杂纳米粘土,具有潜在的生物医学应用前景。研究的第一部分研究了多糖双组分水凝胶配方的制备,然后选择最佳的多糖浓度比例,以确保3d打印结构体的适当形态结构稳定性。第二步的目标是通过调节在先前选择的生物聚合物墨水中掺杂纳米粘土的量来生成具有高打印保真度的3D支架。根据增材制造实验,富含最高纳米填料浓度的藻酸盐- salecan水凝胶最适合3D打印工艺。形态学和结构研究证实了纳米复合材料配方能够有效地生产出具有更高保真度的多孔3d打印结构。形态结构的发现强调了选择组件之间适当比例的含义,因为它们对打印配方和随后的3d打印结构的功能有相当大的影响。因此,从获得的结果来看,这些新型的水凝胶纳米复合材料墨水被认为是有价值的生物材料,具有合适的特征,可用于3D结构的增材制造,具有精确的形状,用于定制再生治疗。
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来源期刊
CiteScore
6.90
自引率
4.80%
发文量
81
期刊介绍: The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.
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