{"title":"Facile Synthesis and Biological Evaluation of Cyclopropyl-Pyrazole\nHybrids in [bmim][PF6]-Water Biphasic System as Antifungal Agents","authors":"P. C. Burde, A. Rahatgaonkar","doi":"10.14233/ajomc.2019.ajomc-p192","DOIUrl":null,"url":null,"abstract":"3-Cyclopropyl-5-(4-substituted)-1-phenyl-4,5-dihydro-1H-pyrazoles derived from corresponding\nchalcones were synthesized and evaluated for their biological activities. A convenient synthesis of a\nlibrary of these compounds in 1-butyl-3-methylimidazolium hexafluorophosphate-water biphasic system\nat ambient temperature has been accomplished. The ionic liquid, [bmim][PF6] and water which are\nimmiscible, has been easily recycled and reused after separation of the products without any noticeable\ndiminution in its activity.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"16 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic & Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14233/ajomc.2019.ajomc-p192","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
3-Cyclopropyl-5-(4-substituted)-1-phenyl-4,5-dihydro-1H-pyrazoles derived from corresponding
chalcones were synthesized and evaluated for their biological activities. A convenient synthesis of a
library of these compounds in 1-butyl-3-methylimidazolium hexafluorophosphate-water biphasic system
at ambient temperature has been accomplished. The ionic liquid, [bmim][PF6] and water which are
immiscible, has been easily recycled and reused after separation of the products without any noticeable
diminution in its activity.
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